Terminology Services

Terms & Acronyms

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Term	Acronym	Vocabulary	Vocabulary Type	Definitions
Point of Departure		Integrated Risk Information System (IRIS) Glossary	Glossary and Key Word List	Definition: The dose-response point that marks the beginning of a low-dose extrapolation. This point can be the lower bound on dose for an estimated incidence or a change in response level from a dose-response model (BMD), or a NOAEL or LOAEL for an observed incidence, or change in level of response.
point of departure	POD	Thesaurus of Terms Used in Microbial Risk Assessment	Thesaurus	Definition 1: The dose-response point that marks the beginning of a low-dose extrapolation. This point can be the lower bound on dose for an estimated incidence or a change in response level from a dose-response model (BMD), or a NOAEL or LOAEL for an observed incidence, or change in level of response. [EPA 2003] Definition 2: A point of departure marks the beginning of extrapolation to lower doses. The POD is an estimated dose (usually expressed in human-equivalent terms) near the lower end of the observed range, without significant extrapolation to lower doses. [EPA 2005a]
Point of Departure	POD	Benchmark Dose Software (BMDS) Glossary of Terms	Glossary and Key Word List	Definition: The point on a dose-response curve established from experimental data, e.g., the benchmark dose, generally corresponding to an estimated low effect level (e.g., 1% to 10% incidence of an effect). Depending on the mode of action and available data, some form of extrapolation below the POD may be employed for low-dose risk assessment or the POD may be divided by a series of uncertainty factors to arrive at a reference dose.
Point of Departure	PoD	Pesticides Glossary	Glossary and Key Word List	Definition: A dose that can be considered to be in the range of observed responses, without significant extrapolation. A PoD can be a data point or an estimated point that is derived from observed dose-response data. A PoD is used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures.
Point of Departure		EPA EV-Outcomes-Health Impacts	Taxonomy	Definition 1: Point on a dose-response curve established from experimental data, e.g., the benchmark dose, generally corresponding to an estimated low effect level (e.g., 1% to 10% incidence of an effect). Depending on the mode of action and available data, some form of extrapolation below the POD may be employed for low-dose risk assessment or the POD may be divided by a series of uncertainty factors to arrive at a reference dose. Acronym: POD [Benchmark Dose Software (BMDS) Glossary of Terms] Definition 2: The dose-response point that marks the beginning of a low-dose extrapolation. This point can be the lower bound on dose for an estimated incidence or a change in response level from a dose-response model (BMD), or a NOAEL or LOAEL for an observed incidence, or change in level of response. [EPA 2003][Thesaurus of Terms Used in Microbial Risk Assessment] Definition 3: A point of departure marks the beginning of extrapolation to lower doses. The POD is an estimated dose (usually expressed in human-equivalent terms) near the lower end of the observed range, without significant extrapolation to lower doses. [EPA 2005a][Thesaurus of Terms Used in Microbial Risk Assessment]

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