Point of Departure POD Benchmark Dose Software (BMDS) Glossary of Terms Glossary and Key Word List Definition: The point on a dose-response curve established from experimental data, e.g., the benchmark dose, generally corresponding to an estimated low effect level (e.g., 1% to 10% incidence of an effect). Depending on the mode of action and available data, some form of extrapolation below the POD may be employed for low-dose risk assessment or the POD may be divided by a series of uncertainty factors to arrive at a reference dose. point of departure POD Thesaurus of Terms Used in Microbial Risk Assessment Thesaurus Definition 1: The dose-response point that marks the beginning of a low-dose extrapolation. This point can be the lower bound on dose for an estimated incidence or a change in response level from a dose-response model (BMD), or a NOAEL or LOAEL for an observed incidence, or change in level of response. [EPA 2003] Definition 2: A point of departure marks the beginning of extrapolation to lower doses. The POD is an estimated dose (usually expressed in human-equivalent terms) near the lower end of the observed range, without significant extrapolation to lower doses. [EPA 2005a] Point of Departure PoD Pesticides Glossary Glossary and Key Word List Definition: A dose that can be considered to be in the range of observed responses, without significant extrapolation. A PoD can be a data point or an estimated point that is derived from observed dose-response data. A PoD is used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. Point of Departure Integrated Risk Information System (IRIS) Glossary Glossary and Key Word List Definition: The dose-response point that marks the beginning of a low-dose extrapolation. This point can be the lower bound on dose for an estimated incidence or a change in response level from a dose-response model (BMD), or a NOAEL or LOAEL for an observed incidence, or change in level of response. Point of Departure EPA EV-Outcomes-Health Impacts Taxonomy Definition 1: Point on a dose-response curve established from experimental data, e.g., the benchmark dose, generally corresponding to an estimated low effect level (e.g., 1% to 10% incidence of an effect). Depending on the mode of action and available data, some form of extrapolation below the POD may be employed for low-dose risk assessment or the POD may be divided by a series of uncertainty factors to arrive at a reference dose. Acronym: POD [Benchmark Dose Software (BMDS) Glossary of Terms] Definition 2: The dose-response point that marks the beginning of a low-dose extrapolation. This point can be the lower bound on dose for an estimated incidence or a change in response level from a dose-response model (BMD), or a NOAEL or LOAEL for an observed incidence, or change in level of response. [EPA 2003][Thesaurus of Terms Used in Microbial Risk Assessment] Definition 3: A point of departure marks the beginning of extrapolation to lower doses. The POD is an estimated dose (usually expressed in human-equivalent terms) near the lower end of the observed range, without significant extrapolation to lower doses. [EPA 2005a][Thesaurus of Terms Used in Microbial Risk Assessment]